ABSTRACT
The primary ovarian lymphoma is a rare disease with poor prognosis. The incidence of autoimmune hemolytic anemia in patients with non-Hodgkin's lymphoma is estimated at 3%. However, a substantial portion of the previously reported cases of ovarian lymphoma actually represented ovarian involvement by more diffuse lymphomatous process. If stringent criteria are used for case selection, true primary ovarian lymphoma usually carries a favorable prognosis. We present a primary malignant lymphoma of ovary accompanied by autoimmune hemolytic anemia in a 29-yr-old patient. After ablative surgery, the hemoglobin level and the reticulocyte count were normalized. One year following surgery and chemotherapy, the patient is alive and disease free.
Subject(s)
Adult , Female , Humans , Anemia, Hemolytic/immunology , Antineoplastic Agents, Hormonal/therapeutic use , Autoimmune Diseases/immunology , Combined Modality Therapy , Lymphoma, Non-Hodgkin/complications , Ovarian Neoplasms/complications , Prednisolone/therapeutic useABSTRACT
The combination of 5-fluorouracil and leucovorin is the most commonly used chemotherapeutic agents in colon cancer. The most frequent adverse effects include mucositis, diarrhea and myelosuppression. But it has never been reported that eosinophilic pneumonia developed. A 50-year-old woman with a history of colon cancer was treated by chemotherapy with a combination of 5-fluorouracil and leucovorin. Progressive dyspnea and bilateral pulmonary interstitial infiltrates developed. Bronchoscopy with bronchoalveolar lavage confirmed pulmonary eosinophilia. Clinical and radiologic aspects of eosinophilic pneumonia cleared after discontinuation of chemotherapy. We report the first case of eosinophilic pneumonia induced by 5-fluorouacil and leucovorin administration in a patient with colon cancer.